Bergsmark J, Gadeholt G
Tidsskr Nor Laegeforen. 1994 Aug 10;114(18):2116-7.
Five patients presented with unusually severe and therapy-resistant rhinitis, sinusitis, and nasal polyps. Long courses of antibiotics did not cure the sinusitis, and recurrences appeared soon after surgical intervention. The patients used non-selective beta blockers for hypertension or as secondary prophylaxis after cardiac infarction, either timolol (n = 4) or propranolol (n = 1), and the nasal problems developed with a latency ranging from a few days up to four years of beta blocker use. Two of the patients discontinued the beta blocker for reasons relating to cardiovascular status and experienced complete remission of the nasal problems without further treatment. In the three remaining patients the therapy was withdrawn. The symptoms cleared within weeks, and did not recur. The patients who needed beta blockade experienced no recurrence when put on beta-1-selective blocker (metoprolol or atenolol).
五名患者表现出异常严重且对治疗有抵抗性的鼻炎、鼻窦炎和鼻息肉。长期使用抗生素未能治愈鼻窦炎，手术干预后很快复发。这些患者因高血压或作为心肌梗死后的二级预防使用非选择性β受体阻滞剂，其中4名患者使用噻吗洛尔，1名患者使用普萘洛尔，鼻腔问题在使用β受体阻滞剂数天至四年的潜伏期后出现。两名患者因心血管状况原因停用β受体阻滞剂，鼻腔问题未经进一步治疗即完全缓解。其余三名患者停止治疗。症状在数周内消退，未再复发。需要β受体阻滞剂的患者改用β1选择性阻滞剂（美托洛尔或阿替洛尔）后未再复发。
