Menendez C, Todd J, Alonso P L, Francis N, Lulat S, Ceesay S, M'Boge B, Greenwood B M
Medical Research Council Laboratories, Fajara, Banjul, The Gambia.
Trans R Soc Trop Med Hyg. 1994 Sep-Oct;88(5):590-3. doi: 10.1016/0035-9203(94)90176-7.
A randomized, double-blind, placebo-controlled community-based trial of oral iron supplementation (200 mg ferrous sulphate daily) administered to multigravid pregnant women by traditional birth attendants (TBAs) was carried out in a rural area of The Gambia. Iron supplementation led to a significant reduction in the prevalence of anaemia and of iron deficiency. Iron supplementation was not accompanied by increased susceptibility to malaria infection; there was no difference in the prevalence and severity of peripheral blood or placental malaria infection between the 2 groups of women. The birth weight of children born to women who received iron prophylaxis was increased by an average of 56 g. It is concluded that oral iron prophylaxis can be successfully delivered through TBAs integrated into a primary health care programme. This simple intervention can produce significant beneficial effects on the health of the mother without inducing increased susceptibility to malaria and has the potential for reducing perinatal mortality by increasing birth weight.
在冈比亚农村地区开展了一项随机、双盲、安慰剂对照的基于社区的试验，由传统助产士（TBAs）对多胎孕妇每日口服补充200毫克硫酸亚铁。补充铁剂导致贫血患病率和缺铁情况显著降低。补充铁剂并未伴随疟疾感染易感性增加；两组女性外周血或胎盘疟疾感染的患病率及严重程度无差异。接受铁剂预防的女性所生孩子的出生体重平均增加了56克。得出的结论是，通过纳入初级卫生保健计划的传统助产士能够成功实施口服铁剂预防。这种简单的干预措施可对母亲的健康产生显著有益影响，而不会增加疟疾易感性，并且有可能通过增加出生体重降低围产期死亡率。
