Fradkin V A, Lodinova L M, Lavrenchik E I
Zh Mikrobiol Epidemiol Immunobiol. 1994 Jul-Aug(4):38-42.
The study of the allergenic properties of thimerosal contained in adsorbed DPT vaccine was carried out. Two variants of this vaccine, with and without thimerosal, as well as thimerosal alone (diluted 1:10,000, which corresponds to the content of this preservative in the vaccine), were used in experiments. The phenomenon of anaphylactic shock, passive dermal anaphylaxis and skin tests were used as test-systems. The injection of each of the two variants of the vaccine induced the state of sensitization in guinea pigs. At the same time no differences in the intensity of manifestations of immediate and delayed hypersensitivity induced by preparations with and without thimerosal were registered. The solution of thimerosal alone exhibited no sensitizing properties.
对吸附型白百破疫苗中含有的硫柳汞的致敏特性进行了研究。该疫苗的两种变体，一种含硫柳汞，一种不含硫柳汞，以及单独的硫柳汞（稀释至1:10000，这与该疫苗中这种防腐剂的含量相对应）被用于实验。将过敏性休克现象、被动皮肤过敏反应和皮肤试验用作测试系统。两种疫苗变体中的每一种注射后均使豚鼠产生致敏状态。同时，未观察到含硫柳汞制剂和不含硫柳汞制剂引起的速发型和迟发型超敏反应表现强度上的差异。单独的硫柳汞溶液未表现出致敏特性。
