Osawa J, Kitamura K, Ikezawa Z, Nakajima H
Department of Dermatology, Yokohama City University School of Medicine, Kanagawa, Japan.
Contact Dermatitis. 1991 Mar;24(3):178-82. doi: 10.1111/j.1600-0536.1991.tb01694.x.
We patch tested 141 patients with 0.05% aq. thimerosal and 222 patients with 0.05% aq. mercuric chloride, including 63 children. The frequency of positive patch test reactions to thimerosal was 16.3%. There was a marked preponderance in the young age groups after vaccination, while none of 36 infants (aged 3-48 months) reacted to thimerosal. Positive reactions to mercuric chloride were found in 23 (10.4%) of 222 patients. We also sensitized guinea pigs with diphtheria-pertussis-tetanus (DPT) vaccine containing 0.01% thimerosal and succeeded in inducing hypersensitivity to thimerosal. From patch testing in humans and animal experiments, it is suggested that 0.01% thimerosal in vaccines can sensitize children, and that hypersensitivity to thimerosal is due to the thiosalicylic part of the molecule and correlates with photosensitivity to piroxicam.
我们用0.05%的硫柳汞水溶液对141例患者进行了斑贴试验，并用0.05%的氯化汞水溶液对222例患者进行了斑贴试验，其中包括63名儿童。硫柳汞斑贴试验阳性反应的发生率为16.3%。接种疫苗后，年轻年龄组的阳性反应明显居多，而36名婴儿（3至48个月大）对硫柳汞均无反应。222例患者中有23例（10.4%）对氯化汞呈阳性反应。我们还用含0.01%硫柳汞的白喉-百日咳-破伤风（DPT）疫苗致敏豚鼠，并成功诱导了对硫柳汞的超敏反应。从人体斑贴试验和动物实验来看，提示疫苗中0.01%的硫柳汞可使儿童致敏，且对硫柳汞的超敏反应归因于分子中的硫代水杨酸部分，并与对吡罗昔康的光敏性相关。
