Iushchuk N D, Akhmedov D R, Frolov V M, Peresadin N A, Khomutianskaia N I
Zh Mikrobiol Epidemiol Immunobiol. 1994 Jul-Aug(4):92-6.
The immune status in 48 typhoid fever (TF) patients has been studied. As revealed in this study, during the fever period of the disease pronounced disturbances in immune homeostasis are observed, which are manifested by T lymphopenia, the prevalence of suppressor subpopulations of T lymphocytes with the prevalence of T helpers, a considerable rise in the level of circulating immune complexes (CIC), mainly highly pathogenic medium- and low-molecular complexes. At the early period of convalescence the preservation of all these signs is indicative of fact that the treat of TF relapse is present. IN the prognosis of the disease the most informative signs are a decrease in the number of T lymphocytes and active (early) rosette-forming cells, an increase in the level of CIC and the presence of 75% and more highly pathogenic medium- and low-molecular complexes among them.
对48例伤寒患者的免疫状态进行了研究。本研究显示，在疾病发热期，观察到免疫稳态明显紊乱，表现为T淋巴细胞减少、抑制性T淋巴细胞亚群占优势且辅助性T淋巴细胞占优、循环免疫复合物（CIC）水平显著升高，主要是高致病性的中低分子复合物。在恢复期早期，所有这些体征持续存在表明存在伤寒复发的可能。在疾病预后方面，最具信息价值的体征是T淋巴细胞和活性（早期）玫瑰花结形成细胞数量减少、CIC水平升高以及其中75%及以上为高致病性的中低分子复合物。
