Warner M A, Warner M E, Martin J T
Mayo Medical School, Rochester, Minnesota.
Anesthesiology. 1994 Dec;81(6):1332-40.
Ulnar neuropathy is well-recognized as a potential complication of procedures performed on anesthetized patients. However, reported outcomes and risk factors for this problem are based on small series and anecdotes.
We retrospectively reviewed the perioperative courses of 1,129,692 consecutive patients who underwent diagnostic and noncardiac surgical procedures with concurrent anesthetic management at the Mayo Clinic from 1957 through 1991 (inclusive). The medical diagnoses of patients who had these procedures were scanned for 26 diagnoses associated with neuropathy. Persistent neuropathy of an ulnar nerve was defined as a sensory or motor deficit of greater than 3 months' duration. Risk factors anecdotally associated with persistent neuropathy were analyzed by comparing patients with an ulnar neuropathy with control subjects in a 1:3 case-control study.
Persistent ulnar neuropathies were identified in 414 patients, a rate of 1 per 2,729 patients. Of these, 38 (9%) patients had bilateral neuropathies. Approximately equal numbers of the neuropathies included sensory loss only or mixed sensory and motor loss. Initial symptoms form most neuropathies were noted more than 24 h after the procedure. Factors associated with persistent ulnar neuropathy included male gender and a duration of hospitalization of more than 14 days (P < 0.01). Neuropathy was more likely to develop in very thin and obese patients than in patients with average body habitus. Neither the type of anesthetic technique nor the patient position was found to be associated with this neuropathy. Of the 382 patients who survived the 1st postoperative yr, 53% regained complete motor function and sensation and were asymptomatic. Of those with neuropathies persisting for more than 1 yr, most had moderate or greater disability from pain or weakness.
These data suggest that perioperative ulnar neuropathies are associated with factors other than general anesthesia and intraoperative positioning. Men at the extremes of body habitus who have prolonged hospitalizations are particularly susceptible to development of ulnar neuropathies.
尺神经病变是麻醉患者手术潜在的并发症,这一点已得到广泛认可。然而,关于该问题的报道结果和风险因素多基于小样本系列研究及个案报道。
我们回顾性分析了1957年至1991年(含)在梅奥诊所接受诊断性及非心脏外科手术并同时接受麻醉管理的1,129,692例连续患者的围手术期病程。对接受这些手术患者的医学诊断进行筛查,以查找与神经病变相关的26种诊断。尺神经持续性病变定义为感觉或运动功能缺损持续超过3个月。在一项1:3病例对照研究中,通过将尺神经病变患者与对照受试者进行比较,分析与持续性神经病变相关的轶事性风险因素。
共识别出414例尺神经持续性病变患者,发生率为每2,729例患者中有1例。其中,38例(9%)患者为双侧神经病变。神经病变中单纯感觉丧失或感觉与运动混合丧失的患者数量大致相等。大多数神经病变的初始症状在手术后24小时以上才被注意到。与尺神经持续性病变相关的因素包括男性以及住院时间超过14天(P<0.01)。与体型正常的患者相比,非常消瘦和肥胖的患者更易发生神经病变。未发现麻醉技术类型及患者体位与该神经病变相关。在术后第1年存活的382例患者中,53%恢复了完全的运动功能和感觉,且无症状。在神经病变持续超过1年的患者中,大多数因疼痛或无力而有中度或更严重的残疾。
这些数据表明,围手术期尺神经病变与全身麻醉和术中体位以外的因素有关。体型处于极端状态且住院时间延长的男性尤其易发生尺神经病变。