在产生链球菌素A-M49的M49型A组链球菌菌株中羊毛硫抗生素结构基因的复制
Duplication of the lantibiotic structural gene in M-type 49 group A streptococcus strains producing streptococcin A-M49.
作者信息
Hynes W L, Friend V L, Ferretti J J
机构信息
Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
出版信息
Appl Environ Microbiol. 1994 Nov;60(11):4207-9. doi: 10.1128/aem.60.11.4207-4209.1994.
Abstract
Streptococcin A-M49 is produced by certain strains of M-type 49 group A streptococci. The structural gene for streptococcin A-M49 was cloned after hybridization with a probe containing the scnA lantibiotic structural gene. Sequence analysis revealed a duplication of the scnA gene; each gene (scnA' and scnA") encoded a 51-amino-acid prepeptide.
摘要
链球菌素A-M49由某些M49型A组链球菌菌株产生。在与含有scnA羊毛硫抗生素结构基因的探针杂交后，克隆了链球菌素A-M49的结构基因。序列分析显示scnA基因存在重复；每个基因（scnA'和scnA"）编码一个51个氨基酸的前肽。
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