Shiotani A, Kawaura M, Fukuda H, Tanaka Y, Sako T, Sasaki S, Sakaguchi R, Kusuyama T, Kawaida M, Kanzaki J
Department of Otolaryngology, School of Medicine, Keio University, Tokyo, Japan.
Auris Nasus Larynx. 1994;21(2):126-31. doi: 10.1016/s0385-8146(12)80032-0.
Small cell carcinoma is a rare tumor of the larynx. We present such a case in a 78-year-old female. The histopathological diagnosis at the time of laryngomicroscopic biopsy was squamous cell carcinoma, upon which basis we initially chose surgical treatment. The surgical specimen, however, revealed small cell carcinoma. Despite the administration of radiotherapy and chemotherapy, the patient died 9 months after initial presentation. We believe that this case illustrates the need for a sufficiently large biopsy specimen in order to arrive at the correct histopathological diagnosis when small cell carcinoma of the larynx is present, and that immunohistochemistry and electron microscopy should be performed to aid the diagnosis.
小细胞癌是一种罕见的喉肿瘤。我们报告一例78岁女性患者。喉镜活检时的组织病理学诊断为鳞状细胞癌，基于此我们最初选择了手术治疗。然而，手术标本显示为小细胞癌。尽管给予了放疗和化疗，患者在初次就诊后9个月死亡。我们认为，该病例表明，当存在喉小细胞癌时，需要足够大的活检标本以得出正确的组织病理学诊断，并且应进行免疫组织化学和电子显微镜检查以辅助诊断。
