Bond S L, Singh S M
Department of Zoology, University of Western Ontario, London, Canada.
Biochem Med Metab Biol. 1994 Aug;52(2):155-9. doi: 10.1006/bmmb.1994.1048.
Differences in Ahd-2 at the DNA sequence level were characterized in mouse strains with variable ethanol preferences. The 5' region and the region surrounding the active site of Ahd-2 were compared to detect differences which could affect ethanol sensitivity. Only minor differences were found among the strains in the two regions. These differences cannot explain their variable ethanol preference and the implications of sequence identities among the divergent strains in these regions has yet to be determined.
在具有不同乙醇偏好的小鼠品系中，对醇脱氢酶2（Ahd-2）在DNA序列水平上的差异进行了表征。比较了Ahd-2的5'区域和活性位点周围区域，以检测可能影响乙醇敏感性的差异。在这两个区域的品系中仅发现了微小差异。这些差异无法解释它们不同的乙醇偏好，并且这些不同品系在这些区域中的序列同一性的影响尚未确定。
