Straube A, Helmchen C, Robinson F, Fuchs A, Büttner U
Department of Neurology, Ludwig-Maximilians-University München, Germany.
J Vestib Res. 1994 Sep-Oct;4(5):327-33.
Some of the clinical hallmarks of lateral medullary infarction--Wallenberg's syndrome--are saccadic dysmetria, smooth pursuit deficit, and lateropulsion of the body. Similar movement disorders are seen in monkeys after local unilateral injection of GABAergic drugs in the caudal fastigial nucleus of monkeys. These include an ipsilateral saccadic hypermetria and a contralateral saccadic hypometria as well as cogwheel smooth pursuit eye movements toward the contralateral side and an ipsiversive lateropulsion of the body. It was previously suggested that the lateral medullary infarction causes a lesion of climbing fibers to the cerebellum. This lack of climbing fiber input increases the activity of ipsilateral Purkinje cells, which consequently provide too much inhibition of the deep cerebellar nuclei.
延髓外侧梗死（即 Wallenberg 综合征）的一些临床特征包括眼球跳动性辨距不良、平稳跟踪缺陷以及身体向患侧偏斜。在猴子的尾侧顶核局部单侧注射 GABA 能药物后，也会出现类似的运动障碍。这些表现包括同侧眼球跳动性测距过度和对侧眼球跳动性测距不足，以及向对侧的齿轮样平稳跟踪眼球运动和身体向同侧偏斜。此前有研究认为，延髓外侧梗死会导致小脑攀缘纤维受损。这种攀缘纤维输入的缺失会增加同侧浦肯野细胞的活性，从而对小脑深部核团产生过度抑制。
