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双侧小脑深部核团损伤后出现眼球扫视辨距障碍和“完整”的平稳跟踪眼球运动。

Saccadic dysmetria and "intact" smooth pursuit eye movements after bilateral deep cerebellar nuclei lesions.

作者信息

Büttner U, Straube A, Spuler A

机构信息

Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany.

出版信息

J Neurol Neurosurg Psychiatry. 1994 Jul;57(7):832-4. doi: 10.1136/jnnp.57.7.832.

DOI:10.1136/jnnp.57.7.832
PMID:8021670
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1073025/
Abstract

Two patients with well defined lesions of midline cerebellar structures including the fastigial nuclei on both sides presented with saccadic hypermetria but well preserved smooth pursuit eye movements. This is a remarkable finding as the oculomotor vermis (lobules VI, VII) and the fastigial nucleus are known to play a part in the control of smooth pursuit eye movements and unilateral fastigial lesions lead to a smooth pursuit deficit to the contralateral side (besides saccadic dysmetria). The results are discussed with regard to related deficits seen in patients with Wallenberg's syndrome and after lesions of the pontine reticular formation.

摘要

两名患者的小脑中线结构出现明确病变,包括双侧顶核,表现为眼球扫视性远视,但平稳跟踪眼球运动保存完好。这是一个显著的发现,因为已知动眼蚓部(小叶VI、VII)和顶核在平稳跟踪眼球运动的控制中起作用,单侧顶核病变会导致对侧平稳跟踪功能缺陷(除了眼球扫视测距障碍)。结合在延髓背外侧综合征患者以及脑桥网状结构病变后出现的相关缺陷对结果进行了讨论。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a5b/1073025/3336cbc51e0c/jnnpsyc00037-0061-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a5b/1073025/3336cbc51e0c/jnnpsyc00037-0061-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6a5b/1073025/3336cbc51e0c/jnnpsyc00037-0061-a.jpg

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本文引用的文献

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Normal and pathological saccadic dysmetria.正常和病理性眼球跳动性辨距障碍。
Brain. 1993 Apr;116 ( Pt 2):337-53. doi: 10.1093/brain/116.2.337.
2
The effect of muscimol micro-injections into the fastigial nucleus on the optokinetic response and the vestibulo-ocular reflex in the alert monkey.向清醒猴子的小脑顶核微量注射蝇蕈醇对视动反应和前庭眼反射的影响。
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小脑顶核双侧损伤:对平稳跟踪加速和非反射性视觉引导扫视的影响。
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