用于治疗肌张力障碍的抗精神病药物。对运动功能和情绪影响之间的相互关系。
Neuroleptic medication for dystonia. Reciprocal relationship between effects on motor function and mood.
作者信息
Young C S, Stewart J B, Fenton G W
机构信息
Department of Psychiatry, Royal Dundee Liff Hospital.
出版信息
Br J Psychiatry. 1994 Sep;165(3):384-6. doi: 10.1192/bjp.165.3.384.
BACKGROUND
The presence of dysphoric symptoms associated with neuroleptic medication is commonly reported.
METHOD
Neuroleptic treatment of a segmental dystonia resulted in a disabling depressive illness, which when treated with antidepressants led to the return of the involuntary movements.
RESULTS
The use of several different antidepressants and neuroleptics confirmed the association between drugs and symptoms. Genetic studies excluded "poor metaboliser status" as a reason for the patient's sensitivity to these drugs.
CONCLUSIONS
The case illustrates a delicate imbalance between dose of neuroleptic medication and depressive symptoms. We should be aware of the possibility of mood changes in patients treated with neuroleptics for a variety of conditions.
背景
与抗精神病药物相关的烦躁症状普遍存在。
方法
对一名节段性肌张力障碍患者进行抗精神病治疗后引发了致残性抑郁症，而使用抗抑郁药治疗后，非自主运动又再次出现。
结果
使用多种不同的抗抑郁药和抗精神病药证实了药物与症状之间的关联。基因研究排除了“代谢不良状态”作为患者对这些药物敏感的原因。
结论
该病例说明了抗精神病药物剂量与抑郁症状之间微妙的失衡关系。我们应意识到，使用抗精神病药治疗各种病症的患者可能会出现情绪变化。
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