Holdsworth S R, Atkins R C, Scott D F, Hayes K
Aust N Z J Med. 1976 Dec;6(6):588-90. doi: 10.1111/j.1445-5994.1976.tb04002.x.
Immunosuppression for renal transplantation is associated with the risk of severe overwhelming infection with ubiquitous but normally relatively harmless micro-organisms. In recent years a number of adult cases of fatal hepatitis due to herpes simplex virus (HSV) infection have been reported. Nearly always immune deficiency was a significant factor. A case of fatal HSV infection with hepatitis following transplantation is reported. The case failed to respond to infusion with the antiviral agent cytosine arabinoside. The presentation, diagnosis and treatment of HSV fulminant hepatitis is discussed.
肾移植的免疫抑制与感染普遍存在但通常相对无害的微生物而导致严重压倒性感染的风险相关。近年来，已有多例成人因单纯疱疹病毒（HSV）感染导致致命性肝炎的病例报道。几乎在所有情况下，免疫缺陷都是一个重要因素。本文报告一例移植后发生致命性HSV感染并伴有肝炎的病例。该病例对抗病毒药物阿糖胞苷的输注无反应。本文讨论了HSV暴发性肝炎的临床表现、诊断和治疗。
