Benador N, Mannhardt W, Schranz D, Braegger C, Fanconi S, Hassam S, Talebzadeh V, Cox J, Suter S
Department of Paediatrics, Hôpital cantonal Universitaire, Geneve, Switzerland.
Eur J Pediatr. 1990 May;149(8):555-9. doi: 10.1007/BF01957691.
We report three cases of neonatal herpes simplex virus (HSV) infection presenting as fulminant hepatitis. None of the patients had clear risk factors for HSV infection and they all died. Antiviral treatment for HSV is currently available but must be administered early in the course of the disease before irreversible liver tissue damage is present. Since the diagnosis may be difficult to establish, we wish to draw the attention of clinicians to the presentation of neonatal HSV infection and suggest that in such cases viral cultures, including culture of liver tissue, should be obtained early and antiviral treatment administered while awaiting the culture results.
我们报告了三例表现为暴发性肝炎的新生儿单纯疱疹病毒（HSV）感染病例。这些患者均无明确的HSV感染危险因素，且均已死亡。目前有针对HSV的抗病毒治疗方法，但必须在疾病过程中尽早给药，以免出现不可逆的肝组织损伤。由于诊断可能难以确立，我们希望引起临床医生对新生儿HSV感染表现的关注，并建议在此类病例中，应尽早进行病毒培养，包括肝组织培养，并在等待培养结果期间给予抗病毒治疗。
