Brasseur G, Favennec L, Perrine D, Chenu J P, Brasseur P
Service d'Ophtalmologie, Université de Rouen, Hópital Ch. Nicolle, Rouen, France.
Cornea. 1994 Sep;13(5):459-62. doi: 10.1097/00003226-199409000-00015.
Acanthamoeba keratitis remains very difficult to treat because of the lack of antiamoebic agents completely effective against cysts. Currently, the recommended treatment includes the use of topical neomycin sulfate, various imidazoles, and propamidine isethionate (Brolene) 0.1% eye drops, a compound of the diamidine family. In the present article, we describe the successful management of two patients with an Acanthamoeba keratitis, treated with hexamidine diisethionate (Desomedine) 0.1% eye drops, another diamidine derivative, which was found amoebicidal in vitro on the isolated Acanthamoeba strains. This is to our knowledge the first report on the amoebicidal effectiveness of hexamidine, simultaneously in vitro and in vivo.
棘阿米巴角膜炎由于缺乏对包囊完全有效的抗阿米巴药物，治疗仍然非常困难。目前，推荐的治疗方法包括使用局部硫酸新霉素、各种咪唑类药物以及0.1%的乙磺半胱氨酸丙脒（Brolene）眼药水，后者是一种二脒类化合物。在本文中，我们描述了两名棘阿米巴角膜炎患者的成功治疗，他们使用了0.1%的二乙磺半胱氨酸己脒（Desomedine）眼药水进行治疗，这是另一种二脒衍生物，在体外对分离出的棘阿米巴菌株具有杀阿米巴作用。据我们所知，这是关于己脒在体外和体内同时具有杀阿米巴效力的首份报告。
