Gatti S, Cevini C, Bruno A, Penso G, Rama P, Scaglia M
Laboratory of Parasitology, Virology Unit, IRCCS, San Matteo, Pavia, Italy.
Antimicrob Agents Chemother. 1998 Sep;42(9):2232-4. doi: 10.1128/AAC.42.9.2232.
Acanthamoeba keratitis is a severe ocular infection secondary to accidental macro- or microscopic trauma of the cornea. Starting in 1985, a dramatic increase of this infection was recorded along with the spread of contact lens use. This protozoal disease is difficult to treat because of the scarcity of efficacious topical and systemic drugs. We evaluated the in vitro effectiveness of povidone-iodine (PVP-I [Betadine]), an agent with broad antibacterial and antiviral activity, compared to that of chlorhexidine (CXD), a cationic antiseptic, on Acanthamoeba isolates from patients with amebic keratitis. The results showed that PVP-I solution from 0.5 to 2.5% has a better antiamebic activity both on trophic and cystic stages of Acanthamoeba spp. than does CXD.
棘阿米巴角膜炎是一种因角膜意外受到宏观或微观创伤而继发的严重眼部感染。自1985年起，随着隐形眼镜使用的普及，这种感染病例急剧增加。由于缺乏有效的局部和全身用药，这种原生动物疾病难以治疗。我们评估了聚维酮碘（PVP-I [碘伏]），一种具有广泛抗菌和抗病毒活性的药物，与阳离子防腐剂洗必泰（CXD）相比，对阿米巴角膜炎患者分离出的棘阿米巴的体外有效性。结果表明，0.5%至2.5%的PVP-I溶液对棘阿米巴属的滋养体和包囊阶段的抗阿米巴活性均优于CXD。
