Jeng G W, Wang C R, Liu M F, Yeh T S, Lee G L, Chen M Y, Wang G R, Lin K T, Chuang C Y, Chen C Y
Department of Internal Medicine, National Taiwan University Hospital, Taipei, R.O.C.
Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi. 1993 May;26(2):86-93.
Two types of autoantibodies and intercellular adhesion molecule-1 (ICAM-1) were measured in patients with vasculitis. There were 13 patients with systemic vasculitis, and 12 with cutaneous vasculitis. The measured antibodies included antiendothelial cell antibodies (AECA) and anti-cardiolipin (ACL) antibodies of three isotypes. Results showed that patients with systemic vasculitis had elevated levels of ICAM-1 and IgG isotype ACL antibodies. Higher levels of ICAM-1 and IgG isotype ACL antibody were found in patients with systemic vasculitis than in those with cutaneous vasculitis. Levels of ICAM-1 and IgG isotype ACL antibodies also decreased after disease activity subsided in patients with systemic vasculitis. Measurement of ICAM-1 and autoantibodies may be useful in evaluating the extent of involvement, and for following the disease course.
对血管炎患者检测了两种自身抗体和细胞间黏附分子-1（ICAM-1）。有13例系统性血管炎患者和12例皮肤血管炎患者。检测的抗体包括抗内皮细胞抗体（AECA）和三种同种型的抗心磷脂（ACL）抗体。结果显示，系统性血管炎患者的ICAM-1和IgG同种型ACL抗体水平升高。系统性血管炎患者的ICAM-1和IgG同种型ACL抗体水平高于皮肤血管炎患者。系统性血管炎患者病情活动消退后，ICAM-1和IgG同种型ACL抗体水平也降低。检测ICAM-1和自身抗体可能有助于评估受累程度及跟踪疾病进程。
