Wang C R, Liu M F, Tsai R T, Chuang C Y, Chen C Y
Department of Internal Medicine, National Taiwan University Hospital, Republic of China.
Clin Rheumatol. 1993 Sep;12(3):375-80. doi: 10.1007/BF02231583.
Circulating intercellular adhesion molecule-1 (ICAM-1) and 3 types of autoantibodies were measured in 30 patients with angiographical or pathological proved vasculitis. There were 18 patients with systemic vasculitis and 12 patients with cutaneous vasculitis. The measured antibodies included anti-endothelial cell antibodies (AECA), anti-cardiolipin (ACL) antibodies of 3 isotypes and anti-neutrophil cytoplasma antibodies (ANCA). The results showed that patients with systemic vasculitis had elevated levels of ICAM-1, AECA and IgG isotype antibody as compared with none or lower in patients with cutaneous vasculitis. Levels of ICAM-1 and IgG isotype ACL antibodies also decreased significantly after disease activity subsided in patients with systemic vasculitis. Measurement of ICAM-1 and autoantibodies may be useful in evaluating the extent of involvement and in following the disease activity of patients with vasculitis.
在30例经血管造影或病理证实的血管炎患者中，检测了循环中的细胞间黏附分子-1（ICAM-1）和3种自身抗体。其中有18例系统性血管炎患者和12例皮肤血管炎患者。所检测的抗体包括抗内皮细胞抗体（AECA）、3种同种型的抗心磷脂（ACL）抗体和抗中性粒细胞胞浆抗体（ANCA）。结果显示，与皮肤血管炎患者无或较低水平相比，系统性血管炎患者的ICAM-1、AECA和IgG同种型抗体水平升高。在系统性血管炎患者疾病活动消退后，ICAM-1和IgG同种型ACL抗体水平也显著下降。检测ICAM-1和自身抗体可能有助于评估血管炎患者的受累程度及跟踪疾病活动情况。
