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犬胆囊排空与充盈动力学的无创评估。一项实时超声研究。

Noninvasive evaluation of kinetics of gallbladder emptying and filling in the dog. A real-time ultrasonographic study.

作者信息

Jonderko K, Ferré J P, Buéno L

机构信息

Department of Pharmacology, INRA, Toulouse, France.

出版信息

Dig Dis Sci. 1994 Dec;39(12):2624-33. doi: 10.1007/BF02087700.

Abstract

Patterns of gallbladder contraction induced by a meal or cerulein were examined by means of real-time ultrasonography in conscious dogs. The postprandial gallbladder emptying was characterized by two parameters of the power-exponential function: the gallbladder half emptying time T1/2 = 47.3 +/- 4.7 min and the curve shape parameter S = 0.866 +/- 0.036. Cerulein infused at stepwise increasing rates of 0.7, 2.2, 7.4, 22.2, and 66.5 pmol/kg/hr, administered each for 10 min, evoked a gallbladder contraction to 87.4 +/- 3.8%, 66.7 +/- 2.4%, 44.5 +/- 1.5%, 25.9 +/- 2.1%, and 11.9 +/- 2.0% of the basal volume, respectively. The dependence of the gallbladder emptying on the dose of cerulein was described by the equation of linear regression y - 21.33 [ln(dose + 1)] + 95.81 (r = -0.963, P < 0.001). Accordingly, the cerulein dose required to evoke a 50% reduction of the gallbladder volume amounted to 7.6 pmol/kg/hr (95% confidence interval: 6.8-8.6 pmol/kg/hr). A plateau at the level of about 44% of the basal gallbladder volume characterized the time-course of the gallbladder emptying between 20 and 60 min of the infusion at a constant rate of 7.4 pmol/kg/hr. On the other hand, the 1-hr infusion of 22.2 pmol/kg/hr evoked a continuous decrease in the gallbladder volume with a nadir of 10.2 +/- 0.7% achieved at 60 min. Refilling of the gallbladder, contracted after a 1-hr infusion of cerulein, was complete within 30 and 60 min after the end of infusion for rates of 7.4 pmol/kg/hr and 22.2 pmol/kg/hr, respectively. The time course of the gallbladder filling after cessation of 1-hr infusion of cerulein at 7.4 pmol/kg/hr was described by the equation of linear regression of relative gallbladder volumes vs time: y = 1.732x + 48.61 (r = 0.739, P < 0.001). Refilling of the gallbladder was faster during the first 30 min (y = 2.191x + 7.13, r = 0.885, P < 0.001) and slower between 30 and 60 min (y = 1.218x + 74.97, r = 0.533, P < 0.001) after the end of a 1-hr infusion of cerulein at a rate of 22.2 pmol/kg/hr.

摘要

通过实时超声检查法,对清醒犬进食或注射蛙皮素后胆囊收缩的模式进行了研究。餐后胆囊排空由幂指数函数的两个参数来表征:胆囊半排空时间T1/2 = 47.3 +/- 4.7分钟,曲线形状参数S = 0.866 +/- 0.036。以0.7、2.2、7.4、22.2和66.5 pmol/kg/小时的逐步递增速率注射蛙皮素,每次注射10分钟,分别引起胆囊收缩至基础容积的87.4 +/- 3.8%、66.7 +/- 2.4%、44.5 +/- 1.5%、25.9 +/- 2.1%和11.9 +/- 2.0%。胆囊排空对蛙皮素剂量的依赖性通过线性回归方程y - 21.33 [ln(剂量 + 1)] + 95.81来描述(r = -0.963,P < 0.001)。因此,引起胆囊容积减少50%所需的蛙皮素剂量为7.6 pmol/kg/小时(95%置信区间:6.8 - 8.6 pmol/kg/小时)。以7.4 pmol/kg/小时的恒定速率输注20至60分钟期间,胆囊排空的时间进程以约基础胆囊容积44%的平台期为特征。另一方面,以22.2 pmol/kg/小时输注1小时引起胆囊容积持续下降,在60分钟时达到最低点10.2 +/- 0.7%。分别以7.4 pmol/kg/小时和22.2 pmol/kg/小时的速率输注蛙皮素1小时后收缩的胆囊,在输注结束后30分钟和60分钟内分别完全重新充盈。以7.4 pmol/kg/小时输注蛙皮素1小时停止后胆囊充盈的时间进程,通过相对胆囊容积与时间的线性回归方程来描述:y = 1.732x + 48.61(r = 0.739,P < 0.001)。以22.2 pmol/kg/小时的速率输注蛙皮素1小时结束后,胆囊在前30分钟内重新充盈更快(y = 2.19x + 7.13,r = 0.885,P < 0.001),在30至60分钟之间较慢(y = 1.218x + 74.97,r = 0.533,P < 0.001)。

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