Schwizer W, Fraser R, Borovicka J, Crelier G, Boesiger P, Fried M
Division of Gastroenterology, University Hospital, Zurich, Switzerland.
Dig Dis Sci. 1994 Dec;39(12 Suppl):101S-103S. doi: 10.1007/BF02300384.
Hitherto it has been impossible to measure noninvasively gastric emptying and motility from multiple regions of the stomach in humans. We describe the development of a novel methodology to achieve this using magnetic resonance imaging (MRI). Initial validation studies performed in five healthy volunteers demonstrated similar gastric emptying curves and secretion rates after ingestion of 10% dextrose labeled with [Gd]DOTA, assessed by MRI ([Gd]DOTA as meal marker) and a simultaneous double-indicator technique. Comparison between MRI and scintigraphy in five patients also gave similar results. Application of newer MRI technology allowing a series of coronal scans 1.2 sec apart permitted quantification of wall motion in the proximal and distal stomach in seven healthy volunteers. These results indicate that MRI provides new insights into the mechanisms responsible for both normal and disordered emptying.
迄今为止，在人类中还无法通过非侵入性方法测量胃多个区域的排空和蠕动情况。我们描述了一种使用磁共振成像（MRI）来实现这一目标的新方法的开发过程。在五名健康志愿者身上进行的初步验证研究表明，摄入用[钆]多胺（[Gd]DOTA）标记的10%葡萄糖后，通过MRI（将[Gd]DOTA作为餐食标记物）和同步双指示剂技术评估，胃排空曲线和分泌率相似。在五名患者中对MRI和闪烁扫描法进行比较也得到了相似的结果。应用更新的MRI技术，能够每隔1.2秒进行一系列冠状面扫描，从而对七名健康志愿者胃近端和远端的壁运动进行了量化。这些结果表明，MRI为正常和异常排空的机制提供了新的见解。
