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胃排空障碍时的异常肠道反馈。

Abnormal intestinal feedback in disorders of gastric emptying.

作者信息

Lin H C

机构信息

Department of Medicine, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048.

出版信息

Dig Dis Sci. 1994 Dec;39(12 Suppl):54S-55S. doi: 10.1007/BF02300372.

DOI:10.1007/BF02300372
PMID:7995217
Abstract

Many patients who complain of postprandial bloating discomfort and episodic nausea and vomiting exhibit abnormally slow gastric emptying of a standard meal during scintigraphic study. Nevertheless, on clinical grounds, the group of slow emptiers would appear to be comprised of two types of patients: (1) those with primary motor dysfunction (pump failure) and (2) those who have normal muscle performance but abnormally intense inhibition of gastric emptying by nutrients in small intestine (too much feedback). Our studies suggest that these two groups may be distinguished by varying the nutrient content in the test meal during multiple studies of gastric emptying.

摘要

许多主诉餐后腹胀不适、发作性恶心和呕吐的患者,在闪烁扫描研究中表现出标准餐的胃排空异常缓慢。然而,基于临床理由,胃排空缓慢的患者群体似乎可分为两类:(1)原发性运动功能障碍(泵衰竭)患者;(2)肌肉功能正常但小肠内营养物质对胃排空的抑制异常强烈(反馈过多)的患者。我们的研究表明,在多次胃排空研究中改变测试餐的营养成分,可能有助于区分这两组患者。

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本文引用的文献

1
Inhibition of gastric emptying by glucose depends on length of intestine exposed to nutrient.葡萄糖对胃排空的抑制作用取决于肠道接触营养素的长度。
Am J Physiol. 1989 Feb;256(2 Pt 1):G404-11. doi: 10.1152/ajpgi.1989.256.2.G404.
2
Inhibition of gastric emptying by sodium oleate depends on length of intestine exposed to nutrient.油酸钠对胃排空的抑制作用取决于肠道接触营养物质的长度。
Am J Physiol. 1990 Dec;259(6 Pt 1):G1031-6. doi: 10.1152/ajpgi.1990.259.6.G1031.
Gut. 2005 Oct;54(10):1384-90. doi: 10.1136/gut.2005.065672. Epub 2005 May 29.
4
Guar attenuates fall in postprandial blood pressure and slows gastric emptying of oral glucose in type 2 diabetes.瓜尔豆可减轻2型糖尿病患者餐后血压下降,并减缓口服葡萄糖的胃排空。
Dig Dis Sci. 2003 Jul;48(7):1221-9. doi: 10.1023/a:1024182403984.
5
Fat intolerance depends on rapid gastric emptying.
Dig Dis Sci. 1999 Feb;44(2):330-5. doi: 10.1023/a:1026606601767.