Azpiroz F
Digestive System Research Unit, Hospital General Vall d'Hebron, Autonomous University of Barcelona, Spain.
Dig Dis Sci. 1994 Dec;39(12 Suppl):18S-19S. doi: 10.1007/BF02300362.
During ingestion of food, the stomach relaxes to accommodate the meal and, subsequently, a progressive gastric contraction parallels gastric emptying. Intestinal nutrients trigger feedback relaxatory mechanisms that regulate gastric tone and, hence, the nutrient load delivered into the small intestine. This regulation of gastric tone is mediated, at least in part, via the vagus. Defective gastric tone is associated with impaired gastric emptying, as seen in patients with postsurgical gastroparesis. However, increased intragastric pressure, corresponding with defective gastric accommodation, induces abdominal symptoms, but does not alter the gastric emptying pattern. These data indicate that gastric emptying is controlled by complementary mechanisms: gastric tone exerts an emptying force, but gastric outlet resistance is also an important regulator.
在摄入食物期间，胃会放松以容纳食物，随后，逐渐增强的胃收缩与胃排空同步进行。肠道内的营养物质触发反馈性舒张机制，该机制调节胃张力，从而调节进入小肠的营养负荷。胃张力的这种调节至少部分是通过迷走神经介导的。胃张力缺陷与胃排空受损有关，如在胃切除术后胃轻瘫患者中所见。然而，与胃容纳功能缺陷相应的胃内压升高会引发腹部症状，但不会改变胃排空模式。这些数据表明，胃排空受互补机制控制：胃张力施加排空力，但胃出口阻力也是一个重要的调节因素。
