Akamine A, Hashiguchi I, Toriya Y, Maeda K
Department of Conservative Dentistry, Kyushu University, Fukuoka, Japan.
Endod Dent Traumatol. 1994 Jun;10(3):121-8. doi: 10.1111/j.1600-9657.1994.tb00536.x.
To investigate the role of plasma cells and macrophages in the development of periapical lesions, we immunohistochemically examined the distribution of these inflammatory cells in experimental induced rat periapical lesions after pulpectomy. The number of ED1-positive mononuclear cells increased rapidly, reached a plateau which remained stable between days 10 and 60, and subsequently decreased. Immunoglobulin (Ig)-bearing plasma cells appeared after 60 days, and, of these, IgG-bearing plasma cells were predominant after 90 days. The radiographic and histopathological findings indicated the development of bone destruction at 10 days which continued until 60 days; tissue repair began to take place after 90 days. The results suggested that macrophages had a close relation to bone destruction and that plasma cells might participate in tissue repair rather than the development of periapical lesions.
为了研究浆细胞和巨噬细胞在根尖周病变发展中的作用，我们采用免疫组织化学方法检测了实验性诱导的大鼠牙髓切除术后根尖周病变中这些炎性细胞的分布。ED1阳性单核细胞数量迅速增加，在第10天至60天之间达到稳定的平台期，随后减少。携带免疫球蛋白（Ig）的浆细胞在60天后出现，其中，携带IgG的浆细胞在90天后占主导地位。影像学和组织病理学结果表明，在第10天出现骨破坏并持续至60天；90天后开始组织修复。结果提示，巨噬细胞与骨破坏密切相关，浆细胞可能参与组织修复而非根尖周病变的发展。
