Miller B D, Wood B L
Division of Child and Adolescent Psychiatry, University of Rochester School of Medicine and Dentistry, NY 14642.
J Am Acad Child Adolesc Psychiatry. 1994 Nov-Dec;33(9):1236-45. doi: 10.1097/00004583-199411000-00004.
The purpose of this study was to determine the suitability of a newly developed experimental paradigm, designed to assess relationships among emotional responsivity, physiologic (autonomic) reactivity, airway reactivity, and pulmonary function in asthmatic children under controlled conditions of ecologically valid emotional stimulation.
Twenty-four children, aged 8 through 17, with moderate to severe asthma viewed the movie, E.T., the Extra-Terrestrial, while having their heart and respiration rate and oxygen saturation continuously measured and recorded. Airway reactivity was assessed by the methacholine challenge test, and pre- and postmovie pulmonary function by spirometry. Self-report of emotion was recorded for targeted scenes.
Findings indicated that emotional responsivity and physiologic reactivity to the movie were associated with increased airway reactivity and with decreased pulmonary function.
The pattern of results suggests cholinergically mediated psychophysiologic pathways of emotional influence in the asthmatic process for some asthmatic children. A heuristic biopsychosocial model of these pathways is presented.
本研究旨在确定一种新开发的实验范式是否适用，该范式旨在评估在生态有效情绪刺激的可控条件下，哮喘儿童的情绪反应性、生理（自主）反应性、气道反应性和肺功能之间的关系。
24名年龄在8至17岁之间的中重度哮喘儿童观看电影《E.T.外星人》，同时持续测量并记录他们的心率、呼吸频率和血氧饱和度。通过乙酰甲胆碱激发试验评估气道反应性，通过肺活量测定法评估电影前后的肺功能。针对特定场景记录情绪的自我报告。
研究结果表明，对电影的情绪反应性和生理反应性与气道反应性增加和肺功能下降有关。
结果模式表明，对于一些哮喘儿童，在哮喘过程中情绪影响存在胆碱能介导的心理生理途径。本文提出了这些途径的启发式生物心理社会模型。
