一种改性酵母甘露聚糖对丝裂霉素-C抗肿瘤活性的增强作用。
Enhancing effect of a modified yeast mannan on antitumor activity of mitomycin-C.
作者信息
Suzuki M, Matsumoto T, Mikami T, Suzuki S
出版信息
Gan. 1976 Aug;67(4):607-9.
A synthetic stearolymannan phosphate designated as SMP-Fr. I-d, consisting of three components, fatty acid, polysaccharide, and phosphate, enhanced the therapeutic effect of Mitomycin-C in mice implanted with 1 x 10(7) cells of Ehrlich carcinoma ascites form. Namely, 50% of the mice survived more than 60 days when ineffective doses of 0.5 mg/kg of Mitomycin-C and 50 mg/kg of SMP-Fr. I-d were administered intraperitoneally once daily for 7 days. SMP-Fr. I-d was found to be virtually non-toxic even in a dose of 1,000 mg/kg intraperitoneally in mice.
一种名为SMP-Fr. I-d的合成硬脂酰甘露聚糖磷酸酯，由脂肪酸、多糖和磷酸盐三种成分组成，增强了丝裂霉素-C对接种1×10⁷个艾氏腹水癌细胞的小鼠的治疗效果。也就是说，当每天腹腔注射无效剂量的0.5毫克/千克丝裂霉素-C和50毫克/千克SMP-Fr. I-d，连续7天时，50%的小鼠存活超过60天。发现SMP-Fr. I-d即使以1000毫克/千克的剂量腹腔注射给小鼠，实际上也是无毒的。
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