Lambert B, Muteganya D, Lepage Y, Boivin Y
Department of Gynecology, Hôtel-Dieu Hospital, University of Montreal, Quebec, Canada.
J Reprod Med. 1994 Aug;39(8):639-42.
We reviewed 94 cases of complex endometrial hyperplasia (CH) with and without atypia to assess some of the clinical and pathologic changes observed on curettage and in hysterectomy specimens. Age, parity, height, weight and nomograms did not differ between CH with or without atypia, and CH associated with endometrial carcinoma. CH without atypia, however, predicted lesser degrees of malignancy as compared to CH with atypia. Progesterone or progestinlike treatment is indicated for CH without atypia along with endometrial monitoring, but CH with atypia necessitates diagnostic and therapeutic hysterectomy whenever fertility is not a priority.
我们回顾了94例伴有或不伴有不典型增生的复杂性子宫内膜增生（CH）病例，以评估刮宫标本和子宫切除标本中观察到的一些临床和病理变化。伴有或不伴有不典型增生的CH以及与子宫内膜癌相关的CH在年龄、产次、身高、体重和列线图方面并无差异。然而，与伴有不典型增生的CH相比，不伴有不典型增生的CH预示着恶性程度较低。对于不伴有不典型增生的CH，除了进行子宫内膜监测外，还需给予孕激素或孕激素类似物治疗，但对于不考虑生育的伴有不典型增生的CH患者，则需要进行诊断性和治疗性子宫切除术。
