Lundberg J O, Hellström P M, Lundberg J M, Alving K
Department of Pharmacology, Karolinska Institute, Stockholm.
Lancet. 1994 Dec 17;344(8938):1673-4. doi: 10.1016/s0140-6736(94)90460-x.
A role for nitric oxide (NO) in ulcerative colitis has been suggested because mucosal NO synthase activity, measured by indirect assays, is increased in this disorder. We directly measured luminal NO in the colons of twelve controls and six patients with active ulcerative colitis. During colonoscopy, gas was aspirated from different parts of the colon and immediately analysed by a chemiluminescence technique. NO concentrations were more than 100 times higher in the patients than in the controls. Luminal NO is rapidly and easily measurable and may be used to monitor inflammatory bowel disease.
一氧化氮（NO）在溃疡性结肠炎中所起的作用已被提出，这是因为通过间接检测所测得的黏膜一氧化氮合酶活性在该疾病中有所增加。我们直接测量了12名对照者和6名活动期溃疡性结肠炎患者结肠内的肠腔一氧化氮。在结肠镜检查期间，从结肠的不同部位抽取气体，并立即通过化学发光技术进行分析。患者体内的一氧化氮浓度比对照者高出100多倍。肠腔一氧化氮能够快速且容易地被检测出来，可用于监测炎症性肠病。
