Parkes S E, Amoaku W M, Muir K R, Willshaw H E, Mann J R
West Midlands Regional Children's Tumour Research Group, Birmingham, UK.
Paediatr Perinat Epidemiol. 1994 Jul;8(3):282-91. doi: 10.1111/j.1365-3016.1994.tb00461.x.
This study of a 30-year population-based dataset investigates further an earlier observation that the incidence of sporadic bilateral retinoblastoma appeared to be increasing in recent years in the West Midlands Health Authority Region (WMHAR). Stringent measures were applied to ensure complete ascertainment of all cases of retinoblastoma in children in the region, resulting in a total of 117 cases diagnosed during the period 1960-89 in the WMHAR. Hospital case notes were abstracted and follow-up data obtained. Incidence rates were calculated. The overall incidence remained constant over the 30-year period, but that of sporadic bilateral tumours increased, with a corresponding decline in familial cases. There was a statistically significant excess seen in Asian children.
这项基于30年人口数据集的研究进一步调查了一个早期观察结果，即西米德兰兹郡卫生局区域（WMHAR）近年来散发性双侧视网膜母细胞瘤的发病率似乎在上升。采取了严格措施以确保该地区儿童视网膜母细胞瘤所有病例的完全确诊，结果在1960年至1989年期间，WMHAR共确诊117例病例。提取了医院病例记录并获得了随访数据。计算了发病率。在这30年期间总体发病率保持不变，但散发性双侧肿瘤的发病率上升，家族性病例相应减少。在亚洲儿童中观察到有统计学意义的超额发病率。
