Funke M, Kopka L, Vosshenrich R, Fischer U, Ueberschaer A, Oestmann J W, Grabbe E
Department of Radiology, Georg-August Universitat, Goettingen, Germany.
Radiology. 1995 Jan;194(1):77-81. doi: 10.1148/radiology.194.1.7997586.
To evaluate the usefulness of broadband ultrasound attenuation in the prediction of osteoporosis.
Broadband ultrasound attenuation measurements of the calcaneus and dual x-ray absorptiometry (DXA) measurements of the lumbar spine and the femoral neck were obtained in 400 patients (295 female and 105 male), 135 of whom were classified as having osteoporosis. Correlation coefficients between broadband ultrasound attenuation and DXA were calculated.
Patients with osteoporosis showed a statistically significant decrease in broadband ultrasound attenuation compared with healthy patients (59.7 dB/MHz +/- 1.3 [standard deviation] vs 75.1 dB/MHz +/- 0.8). Broadband ultrasound attenuation correlated statistically significantly with vertebral bone density (r = .49) and femoral neck density (r = .52). At a broadband ultrasound attenuation index of 64 dB/MHz, the sensitivity and specificity were both 85% for patients with osteoporotic fractures.
Broadband ultrasound attenuation can be used to help differentiate between patients with osteoporosis and healthy patients and seems to be useful in the prediction of fracture risk.
评估宽带超声衰减在预测骨质疏松症方面的效用。
对400例患者（295例女性和105例男性）进行跟骨宽带超声衰减测量以及腰椎和股骨颈的双能X线吸收测定（DXA），其中135例被归类为患有骨质疏松症。计算宽带超声衰减与DXA之间的相关系数。
与健康患者相比，骨质疏松症患者的宽带超声衰减在统计学上有显著降低（59.7 dB/MHz±1.3[标准差]对75.1 dB/MHz±0.8）。宽带超声衰减与椎体骨密度（r = 0.49）和股骨颈密度（r = 0.52）在统计学上有显著相关性。对于骨质疏松性骨折患者，在宽带超声衰减指数为64 dB/MHz时，敏感性和特异性均为85%。
宽带超声衰减可用于帮助区分骨质疏松症患者和健康患者，并且似乎在预测骨折风险方面有用。
