DeMarco M, Uhl L, Fields L, Pacini D, Gorlin J B, Kruskall M S
Department of Pathology, Charles A. Dana Research Institute, Boston, Massachusetts.
Transfusion. 1995 Jan;35(1):58-60. doi: 10.1046/j.1537-2995.1995.35195090664.x.
Alloantibodies to the low-frequency antigen Scianna 2 (Sc2) are uncommon and not previously reported to cause immune hemolysis.
A group B, Rh-negative infant born to a group B, Rh-positive mother had a 2+ direct antiglobulin test, as well as modest hyperbilirubinemia and a hematocrit of 45 percent. Ongoing immune hemolysis led to a hematocrit of 17.3 percent on Day 20 of life, and the infant required hospitalization and red cell transfusions. The routine maternal antibody screen was negative, but anti-Sc2 was detected during work-up for a low-frequency red cell antigen, and the father's red cells typed as Sc:1,2.
Anti-Sc2 can cause clinically significant hemolytic disease of the newborn. Although the antibody is uncommon, its frequency and hemolytic potential may be underappreciated, in part because investigations often are not carried out in the infant whose red cells are ABO-incompatible with maternal blood.
针对低频抗原斯恰纳2（Sc2）的同种抗体并不常见，此前未有报道其可引起免疫性溶血。
一名B型Rh阴性婴儿，其母亲为B型Rh阳性，该婴儿直接抗人球蛋白试验呈2+，同时伴有中度高胆红素血症，血细胞比容为45%。持续的免疫性溶血导致婴儿出生后第20天时血细胞比容降至17.3%，该婴儿需要住院治疗并接受红细胞输血。母亲的常规抗体筛查为阴性，但在对低频红细胞抗原进行检查时检测到了抗Sc2，父亲的红细胞血型为Sc:1,2。
抗Sc2可导致具有临床意义的新生儿溶血病。尽管这种抗体并不常见，但其发生率和溶血潜能可能未得到充分认识，部分原因是通常不会对红细胞与母亲血液ABO血型不相容的婴儿进行相关检查。
