[接受干扰素治疗的急性乙型病毒性肝炎患者白细胞的干扰素反应及自然杀伤活性]

[The interferon reaction of the leukocytes and the natural killer activity in patients with acute viral hepatitis B undergoing interferon treatment].

作者信息

Golban T D, Cheshik S G, Kuznetsov V P, Beliaev D L, Grishchenko S V, Morgunov K M, Babaiants A A, Polikushina O E, Antonenko S M

出版信息

Vopr Virusol. 1994 Jul-Aug;39(4):177-9.

PMID:7998397

Abstract

The interferon response of leukocytes (IRL) alpha and gamma as well as the functional activity of natural killers (NK) were studied in patients with the verified diagnosis of acute viral hepatitis B (AVH-B) treated with leukinferon (a preparation of natural interferon-alpha and cytokines) and reaferon (recombinant alpha 2 interferon). The effect of therapy with LF and RF in patients with AVH-B manifested by an increase in the functional activity of NK up to complete normalization after termination of the course of therapy. In the group of patients treated with LF as a result of therapy IRL-alpha increased by the end of the treatment and in the convalescence period. The observed activation of NK and the IF-alpha system under the effect of IF preparations in patients with AVH-B correlated with enhanced elimination of HBsAg.

摘要

在经确诊为急性乙型病毒性肝炎（AVH - B）的患者中，研究了白细胞干扰素反应（IRL）α和γ以及自然杀伤细胞（NK）的功能活性。这些患者接受了白细胞干扰素（一种天然干扰素α和细胞因子的制剂）和利夫隆（重组α2干扰素）治疗。LF和RF治疗对AVH - B患者的影响表现为，NK功能活性增加，直至治疗疗程结束后完全恢复正常。在接受LF治疗的患者组中，治疗结束时及恢复期IRL -α增加。在AVH - B患者中，IF制剂作用下观察到的NK和IF -α系统激活与HBsAg清除增强相关。