急性病毒性肝炎患者的自然杀伤活性
Natural killer activity in patients with acute viral hepatitis.
作者信息
Chemello L, Mondelli M, Bortolotti F, Schiavon E, Pontisso P, Alberti A, Rondanelli E G, Realdi G
出版信息
Clin Exp Immunol. 1986 Apr;64(1):59-64.
Using the natural killer (NK) sensitive K562 cell line, enhanced NK cell cytotoxicity was demonstrable early in the course of acute hepatitis B while normal values were obtained in patients studied during convalescence. No evidence of enhanced NK activity was instead obtained in the course of acute non-A, non-B hepatitis. Serum levels of alpha-interferon, as determined by radioimmunoassay (RIA), were significantly increased in patients with acute hepatitis B showing enhanced NK cell activity but not in those with acute non-A, non-B hepatitis and normal NK cell activity. These results suggest that natural cytotoxicity may play a role early in the course of acute hepatitis type B, before antigen-specific T lymphocytes become fully operative.
利用对自然杀伤（NK）细胞敏感的K562细胞系，在急性乙型肝炎病程早期可证实NK细胞的细胞毒性增强，而在恢复期研究的患者中获得的是正常值。相反，在急性非甲非乙型肝炎病程中未发现NK活性增强的证据。通过放射免疫测定（RIA）测定，急性乙型肝炎患者血清α-干扰素水平显著升高，这些患者显示出NK细胞活性增强，而急性非甲非乙型肝炎患者及NK细胞活性正常的患者血清α-干扰素水平未升高。这些结果表明，在抗原特异性T淋巴细胞充分发挥作用之前，自然细胞毒性可能在急性乙型肝炎病程早期发挥作用。
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