Milev N, Veselinova A
Vet Med Nauki. 1976;13(10):67-73.
Pigs vaccinated with the lapinized K strain were studied by the immunofluorescence method, through bioassay on rabbits, and histopathologically. It was found that virus K is retained up to the 12th day post vaccination. If later on the presence of a virus was demonstrated it was believed that a wild virus participated. The virus was found in the spleen, lymph nodes, tonsils, and occasionally in the kidneys. Histologically, there were changes in the central nervous system under the form of nonsuppurative meningoencephalitis, dystrophic and fibroblastic proliferations in the kidneys, and necrobiotic and necrotic areas in the liver. They proved analogous to the changes found in spontaneously affected pigs; it was believed that there was no difference in the tropism of the vaccinal and the wild virus of swine fever. The results obtained improve the laboratory diagnostics of the classic form of swine fever.
对用兔化K株疫苗接种的猪进行了免疫荧光法研究、兔体生物测定及组织病理学研究。结果发现，接种疫苗后第12天仍可检测到病毒K。如果之后证实有病毒存在，则认为有野生病毒参与。在脾脏、淋巴结、扁桃体中发现了病毒，偶尔在肾脏中也能发现。组织学检查发现，中枢神经系统出现非化脓性脑膜脑炎，肾脏出现营养不良性和纤维母细胞增生，肝脏出现坏死和坏死区域。这些变化与自然感染猪所发现的变化相似；人们认为猪瘟疫苗病毒和野生病毒的嗜性没有差异。所获得的结果改进了猪瘟经典型的实验室诊断方法。
