Stoianov V, Vachev B, Milev N, Ganovski D, Matovski A
Vet Med Nauki. 1976;13(8):62-7.
Investigations were carried out on the presence of carriers and the excretion of the virulent swine fever virus in pigs vaccinated with the lapinized vaccine strain K. On the 15th, 25th, and 35th day following injection with the virulent virus a pig was killed each time and material was taken for morphologic studies and immunofluorescence microscopy. The results of the investigations were negative except for two pigs the cerebrum of which showed perivascular, slightly to moderately expressed lymphoid-cell agglomerations as well as a weakly manifested perivascular edema. Material of the killed animals was used to infect unvaccinated susceptible pigs in which the presence of the virus had not been demonstrated. No clinical and morphologic data or immunofluorescence microscopy demonstration proved the presence of a virus upon exposure of animals to pigs that were injected with a virulent virus. Hematologic studies revealed leukopenia, lower percent of hemoglobin, and a drop in the erythrocyte count following injection with the virulent virus. After a certain period of time this condition was overcome. These experiments showed that when a virulent virus gains access to pigs that have become immune after vaccination with the K vaccinal strain of the swine fever virus does not persist longer than the seventh day and does not cause the development of latent or a clinically manifested infectious process.
对接种兔化疫苗株K的猪体内带毒情况及强毒猪瘟病毒的排泄情况进行了研究。在注射强毒病毒后的第15天、第25天和第35天，每次宰杀1头猪，并采集材料进行形态学研究和免疫荧光显微镜检查。研究结果均为阴性，只有2头猪的大脑出现血管周围轻度至中度表达的淋巴细胞聚集以及轻度的血管周围水肿。将宰杀动物的材料用于感染未接种疫苗且未证明感染病毒的易感猪。动物接触注射强毒病毒的猪后，没有临床和形态学数据或免疫荧光显微镜检查证明存在病毒。血液学研究显示，注射强毒病毒后出现白细胞减少、血红蛋白百分比降低和红细胞计数下降。经过一段时间后，这种情况得到克服。这些实验表明，当强毒病毒接触到用猪瘟病毒K疫苗株免疫后的猪时，病毒不会持续超过第7天，也不会引发潜伏性或临床表现出的感染过程。
