用宋内志贺菌I相抗原接种后豚鼠眼睛的免疫情况。
Immunity of the guinea pig's eye after vaccination with Shigella sonnei phase I antigen.
作者信息
Kerekes L
出版信息
Acta Microbiol Acad Sci Hung. 1976;23(4):353-8.
A total of 8 doses, each containing 10(9) live or heated cells of pure phase I antigen of Shigella sonnei and Plesiomonas shigelloides, was administered into the conjunctival sac of guinea pigs during a 3-week period. The eyes were challenged with virulent S. sonnei. The vaccines protected the eyes in 50-80% to the minimum infecting dose andin 20-50% to 3 MID. The peak of immunity began to decrease after the 26th day and on the 56th day it was practically nil. Vaccination caused histological changes in the conjunctiva but not in the cornea.
在3周时间内，将总共8剂疫苗（每剂含有10⁹个宋内志贺菌和类志贺邻单胞菌纯I相抗原的活细胞或热灭活细胞）接种到豚鼠的结膜囊中。然后用强毒力的宋内志贺菌攻击眼睛。这些疫苗对50 - 80%的最小感染剂量以及20 - 50%的3倍最小感染剂量具有眼部保护作用。免疫峰值在第26天后开始下降，到第56天时实际上已消失。接种疫苗导致结膜出现组织学变化，但角膜未出现变化。
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