Kira J
Department of Neurology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Mol Neurobiol. 1994 Apr-Jun;8(2-3):139-45. doi: 10.1007/BF02780664.
Human T-lymphotropic virus type 1 (HTLV-I) is a pathogenic retrovirus associated with a chronic progressive myelopathy, termed HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP), as well as adult T-cell leukemia (ATL). A chronic inflammatory process has been implicated in HAM/TSP by a pathological study, but the exact mechanism still remains unknown. To understand better the complex mechanism of disease induction by HTLV-I, I studied the spreading pattern of HTLV-I in both peripheral blood mononuclear cells (PBMNCs) and central nervous system (CNS) tissues in patients with HAM/TSP using a quantitative polymerase chain reaction (PCR) method. My results indicated the primary event to be the efficient replication of HTLV-I in vivo, whereas HTLV-I is likely to be present in the constituent cells of the CNS in addition to the infiltrating mononuclear cells.
人类嗜T淋巴细胞病毒1型（HTLV-I）是一种致病性逆转录病毒，与一种慢性进行性脊髓病相关，称为HTLV-I相关脊髓病（HAM）/热带痉挛性截瘫（TSP），以及成人T细胞白血病（ATL）。一项病理学研究表明，慢性炎症过程与HAM/TSP有关，但确切机制仍不清楚。为了更好地理解HTLV-I诱导疾病的复杂机制，我使用定量聚合酶链反应（PCR）方法研究了HTLV-I在HAM/TSP患者外周血单个核细胞（PBMNC）和中枢神经系统（CNS）组织中的传播模式。我的结果表明，主要事件是HTLV-I在体内的有效复制，而除了浸润的单核细胞外，HTLV-I可能还存在于CNS的组成细胞中。
