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Enhancement of human immunodeficiency virus production by natural lymphotoxin.

作者信息

Matsuyama T, Hamamoto Y, Kobayashi S, Kurimoto M, Minowada J, Kobayashi N, Yamamoto N

机构信息

Department of Virology and Parasitology, Yamaguchi University School of Medicine, Japan.

出版信息

Med Microbiol Immunol. 1988;177(4):181-7. doi: 10.1007/BF00211217.

DOI:10.1007/BF00211217
PMID:3262193
Abstract

The effect of natural lymphotoxin (n-LT) on CD4+ MOLT-4 cells and those cells producing human immunodeficiency virus (HIV), MOLT-4/HIVHTLV-IIIB cells, was studied. Four days after treatment with n-LT, a significant cytotoxic/cytostatic effect was observed predominantly on MOLT-4/HIVHTLV-IIIB cells. Furthermore, with regard to the production of HIV, an almost 3- to 5-fold increase of viral particles was observed in MOLT-4/HIVHTLV-IIIB cells 6 h after treatment with n-LT. These data indicate the possibility that this cytotoxic factor is one of the responsible molecules in the pathogenesis of the acquired immunodeficiency syndrome (AIDS).

摘要

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Altered production of tumour necrosis factors alpha and beta and interferon gamma by HIV-infected individuals.感染HIV的个体肿瘤坏死因子α和β以及干扰素γ的产生发生改变。
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Proc Natl Acad Sci U S A. 1990 Dec;87(24):9620-4. doi: 10.1073/pnas.87.24.9620.
Nature. 1984;312(5996):721-4. doi: 10.1038/312721a0.
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Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells.通过将正常人脐带血白细胞与人类白血病T细胞共同培养而获得的脐带T细胞系中的C型病毒颗粒。
Nature. 1981 Dec 24;294(5843):770-1. doi: 10.1038/294770a0.
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Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. 3. Analysis of mechanism.迟发型超敏反应中可溶性抗原和淋巴细胞介导的细胞毒性。3. 机制分析。
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Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes.形成玫瑰花结的人淋巴细胞系。I. 胸腺衍生淋巴细胞起源的建立及证据。
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Proposal of standardized methods and reference for assaying recombinant human tumor necrosis factor.重组人肿瘤坏死因子检测的标准化方法及参考建议。
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Tumor promoter, TPA, enhances replication of HTLV-III/LAV.肿瘤促进剂佛波酯（TPA）可增强人嗜T淋巴细胞病毒III型/淋巴腺病相关病毒（HTLV-III/LAV）的复制。
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Effect of culture supernatant of MT-2 cells on human immunodeficiency virus-producing cells, MOLT-4/HIVHTLV-IIIB cells.MT-2细胞培养上清液对产生人免疫缺陷病毒的细胞——MOLT-4/HIVHTLV-IIIB细胞的影响。
Jpn J Cancer Res. 1988 Feb;79(2):156-9. doi: 10.1111/j.1349-7006.1988.tb01571.x.