Richardson L S, Ting R C, Gallo R C, Wu A M
Int J Cancer. 1975 Mar 15;15(3):451-6. doi: 10.1002/ijc.2910150311.
Cordycepin (3'-deoxyadenosine) was previously shown to inhibit virus production induced by iododeoxyuridine from murine fibroblasts (Wu et al., 1972). We now report that the inhibitory effect of cordycepin results in a reduction of the number of cells producing virus as measured by the infectious center assay and fluorescent antibody technique. Cordycepin has a much greater inhibitory effect on viral replication than on transformation of normal rat kidney cells by murine sarcoma virus since viral production was greatly reduced (seven- to 35-fold) with 5-10 mug/ml of cordycepin while viral transformation was only slightly inhibited (two-fold reduction in focus-forming units) with the same concentration of cordycepin. Inhibition of viral production is most effective if the compound is present during the first 24 h after injection.
虫草素（3'-脱氧腺苷）先前已被证明可抑制碘脱氧尿苷诱导的小鼠成纤维细胞产生病毒（Wu等人，1972年）。我们现在报告，通过感染中心测定法和荧光抗体技术测量，虫草素的抑制作用导致产生病毒的细胞数量减少。虫草素对病毒复制的抑制作用比对小鼠肉瘤病毒转化正常大鼠肾细胞的抑制作用大得多，因为用5-10微克/毫升的虫草素可使病毒产生大幅减少（7至35倍），而相同浓度的虫草素仅略微抑制病毒转化（焦点形成单位减少两倍）。如果该化合物在注射后的头24小时内存在，则对病毒产生的抑制最为有效。
