Hozumi Y, Imaizumi T, Kondo S
Department of Dermatology, Yamagata University School of Medicine, Japan.
J Dermatol Sci. 1994 Jul;7 Suppl:S33-8. doi: 10.1016/0923-1811(94)90033-7.
We investigated the effect of cyclosporin, as well as minoxidil, testosterone, estradiol and corticosteroid on the hair growth on the hairy part of nude mice. Aliquots of solutions of cyclosporin and other agents were applied once per every day topically on the tails and the lower backs of 5 week-old BALB/c nude mice, for as long as 6 weeks. Cyclosporin prolonged the hair-existing phase of the hair cycle, but did not change the term of the hair cycle, i.e., the resting phase was not affected. Minoxidil, testosterone and estradiol did not influence the hair growth cycle. Combination of cyclosporin and other agents demonstrated that there was neither additive nor synergistic effect, but a high dose of corticosteroid inhibit the cyclosporin effect, as well as suppressing completely the reappearance of the growing phase.
我们研究了环孢素以及米诺地尔、睾酮、雌二醇和皮质类固醇对裸鼠多毛部位毛发生长的影响。将环孢素和其他药物的溶液等分试样每天一次局部涂抹于5周龄BALB/c裸鼠的尾巴和下背部，持续6周。环孢素延长了毛发周期的毛发生长期，但未改变毛发周期的时长，即休止期未受影响。米诺地尔、睾酮和雌二醇未影响毛发生长周期。环孢素与其他药物联合使用表明既无相加作用也无协同作用，但高剂量皮质类固醇会抑制环孢素的作用，并完全抑制生长期的再次出现。
