Wu Y, Zheng W, Sellers T A, Kushi L H, Bostick R M, Potter J D
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454-1015.
Cancer Causes Control. 1994 Sep;5(5):395-400. doi: 10.1007/BF01694752.
To test the hypothesis that a high intake of dietary cholesterol and fat is associated with elevated risks of lung cancer, we analyzed data from a population-based, prospective, cohort study conducted among 41,837 postmenopausal Iowa (United States) women who completed, in 1986, a comprehensive mailed questionnaire including information on usual intake of 127 food items. All cohort members were followed for cancer incidence through the statewide cancer registry. By 1991, after six years of follow-up, 272 incident lung-cancer cases were identified. After controlling for total energy intake and other confounding factors, dietary cholesterol, total fat, and animal fat were unrelated to lung cancer risk. Intake in the upper three quartiles of plant-derived fat, however, was related to a 30 to 40 percent lower incidence of lung cancer, comparative with those in the lowest quartile, with more pronounced reduction in risk observed among smokers (relative risk = 0.6, 95 percent confidence interval = 0.4-0.9). This prospective cohort study suggests that high intake of fat of plant origin may be associated with reduced risk of lung cancer, while dietary cholesterol and animal fat intake is unrelated to the etiology of this malignancy in postmenopausal women.
为了验证膳食胆固醇和脂肪的高摄入量与肺癌风险升高相关这一假设，我们分析了一项基于人群的前瞻性队列研究的数据，该研究在41837名爱荷华州（美国）绝经后女性中进行，她们于1986年完成了一份综合邮寄问卷，其中包括127种食物的通常摄入量信息。通过全州癌症登记处对所有队列成员的癌症发病率进行随访。到1991年，经过六年的随访，共确定了272例肺癌新发病例。在控制了总能量摄入和其他混杂因素后，膳食胆固醇、总脂肪和动物脂肪与肺癌风险无关。然而，植物源性脂肪摄入量处于上三个四分位数的人群，与处于最低四分位数的人群相比，肺癌发病率降低了30%至40%，在吸烟者中观察到的风险降低更为明显（相对风险=0.6，95%置信区间=0.4 - 0.9）。这项前瞻性队列研究表明，植物源性脂肪的高摄入量可能与肺癌风险降低有关，而膳食胆固醇和动物脂肪摄入量与绝经后女性这种恶性肿瘤的病因无关。
