通过原位杂交检测口腔黏膜良性、癌前和恶性病变中的人乳头瘤病毒（HPV）DNA。

Detection of HPV DNA by in situ hybridization in benign, premalignant and malignant lesions of the oral mucosa.

作者信息

González-Moles M A, Ruiz-Avila I, González-Moles S, Martinez I, Ceballos A, Nogales F

机构信息

Department of Oral Medicine, School of Dentistry, University of Granada.

出版信息

Bull Group Int Rech Sci Stomatol Odontol. 1994 Sep-Dec;37(3-4):79-85.

PMID:8000233

Abstract

Evidence has accumulated in recent years that relates certain types of human papillomaviruses (HPV) to the development of some tumors. We use in situ hybridization to study DNA from HPV 6/11, 16/18 and 31/33/35 in 6 squamous papillomas, 18 hyperkeratotic/acanthosis lesions with and without dysplasia (5 and 13 cases respectively) and 27 squamous cell carcinomas of the oral mucosa. HPV DNA was found in 66% of squamous papillomas, 38.4% of hyperkeratotic/acanthosis lesions without dysplasia, 60% of epithelial dysplasia and 37% of squamous cell carcinomas. HPV DNA 6/11 was the most common type found, and in squamous cell carcinomas HPV DNA appear more frequently in well differentiated tumors.

摘要

近年来，越来越多的证据表明某些类型的人乳头瘤病毒（HPV）与某些肿瘤的发生有关。我们采用原位杂交技术，对6例鳞状乳头状瘤、18例有或无发育异常的角化过度/棘皮症病变（分别为5例和13例）以及27例口腔黏膜鳞状细胞癌中的HPV 6/11、16/18和31/33/35的DNA进行研究。在66%的鳞状乳头状瘤、38.4%无发育异常的角化过度/棘皮症病变、60%的上皮发育异常以及37%的鳞状细胞癌中发现了HPV DNA。HPV DNA 6/11是最常见的类型，并且在鳞状细胞癌中，HPV DNA在高分化肿瘤中出现的频率更高。