关于口腔扁平苔藓、人类疱疹病毒和人乳头瘤病毒之间可能存在的关联的调查。
Investigation into a possible association between oral lichen planus, the human herpesviruses, and the human papillomaviruses.
作者信息
OFlatharta Cathal, Flint Stephen R, Toner Mary, Butler David, Mabruk Mohamed J E M F
机构信息
Department of Pathology, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Ireland.
出版信息
Mol Diagn. 2003;7(2):73-83. doi: 10.1007/BF03260023.
BACKGROUND
Oral lichen planus (OLP) is a chronic relapsing cell-mediated condition of unknown etiology. The purpose of this study was to ascertain if the human herpesviruses (HHVs) or human papillomaviruses (HPVs) act as possible factors or co-factors in the pathogenesis of OLP.
METHODS
Thirty-eight histologically confirmed OLP and 20 normal control buccal mucosa tissue samples were analyzed. Polymerase chain reaction analysis was employed to detect members of the HHV and HPV families.
RESULTS
The Epstein-Barr virus and HHV-7 were detected in a small percentage of tissue samples. However, HPV-16 was detected in 26.3% of OLP samples and 0% of the normal control tissues. The epidermodysplasia verruciformis-related HPV types were detected in 42% of OLP samples and 45% of normal control samples.
CONCLUSION
The results of this study do not suggest a causative role for members of the HHV family in the pathology of OLP. However, a statistical association was found between HPV-16 presence and OLP.
背景
口腔扁平苔藓（OLP）是一种病因不明的慢性复发性细胞介导疾病。本研究的目的是确定人类疱疹病毒（HHV）或人乳头瘤病毒（HPV）是否在OLP的发病机制中作为可能的因素或辅助因素起作用。
方法
分析了38例经组织学证实的OLP和20例正常对照颊黏膜组织样本。采用聚合酶链反应分析检测HHV和HPV家族的成员。
结果
在一小部分组织样本中检测到爱泼斯坦-巴尔病毒和HHV-7。然而，在26.3%的OLP样本中检测到HPV-16，而正常对照组织中未检测到。在42%的OLP样本和45%的正常对照样本中检测到疣状表皮发育不良相关的HPV类型。
结论
本研究结果不表明HHV家族成员在OLP病理中起致病作用。然而，发现HPV-16的存在与OLP之间存在统计学关联。
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