Yamaguchi H, Kaku H, Onodera T A, Kurokawa R, Morisada M
Department of Pathology, School of Medicine, Keio University, Tokyo, Japan.
Exp Toxicol Pathol. 1994 Aug;46(3):237-41. doi: 10.1016/S0940-2993(11)80090-4.
Bartter's syndrome is a genetic disorder which has very rarely been clinically encountered. However, it is of specific interest with respect to the hormonal layer of the kidney, including renin, angiotensin and aldosterone as well as biological alteration of the various electrolytes. The fundamental morphological manifestation of this disorder is known to be hyperplasia of juxtaglomerular cells, although, until now, no experimental studies on this condition have been reported. Demonstrated in this initial study is the remarkable hyperplasia of the juxtaglomerular cells in all terminal portions of the afferent glomerular arterioles situated near the hilum of the glomerular tuft, using a low-dose, long-term administration of calcium chelating agents. This hyperplasia reported in this paper may lead to a new procedure in the analysis of this syndrome.
巴特综合征是一种临床上极为罕见的遗传性疾病。然而，就肾脏的激素层面而言，它具有特殊意义，涉及肾素、血管紧张素和醛固酮，以及各种电解质的生物学改变。已知这种疾病的基本形态学表现是球旁细胞增生，尽管迄今为止尚未有关于这种情况的实验研究报道。在这项初步研究中，通过低剂量、长期给予钙螯合剂，证实了位于肾小球丛肾门附近的入球小动脉所有终末部分的球旁细胞显著增生。本文报道的这种增生可能会为该综合征的分析带来一种新方法。
