Hnatyszyn H J, Kossovsky N, Gelman A, Sponsler E
Department of Pathology and Laboratory Medicine, University of California, Los Angeles School of Medicine.
PDA J Pharm Sci Technol. 1994 Sep-Oct;48(5):247-54.
Parenteral drug delivery systems have the potential to make drugs both safer and more effective. While research in this field has been active for over 30 years, the current fiscal constraints of health care delivery add a greater degree of urgency to finding a working system. The three competing technologies currently under development include prodrug or zymogen-like systems, simple soluble macromolecular systems, and complex particulate multicomponent systems. In this review, the advantages, disadvantages, and areas for further development of these three basic technology systems are compared and contrasted; the biophysical constraints are considered; and a model solution system using surface modified nanocrystalline ceramics is described.
肠胃外给药系统有可能使药物更安全、更有效。尽管该领域的研究已经活跃了30多年，但当前医疗保健服务的财政限制给寻找一个可行的系统增添了更大的紧迫性。目前正在开发的三种相互竞争的技术包括前药或类酶原系统、简单的可溶性高分子系统以及复杂的颗粒多组分系统。在这篇综述中，对这三种基本技术系统的优点、缺点和进一步发展的领域进行了比较和对比；考虑了生物物理限制因素；并描述了一种使用表面改性纳米晶陶瓷的模型溶液系统。
