Langer Robert
MIT,Cambridge,MA,USA.
Q Rev Biophys. 2015 Nov;48(4):424-8. doi: 10.1017/S0033583515000165.
Materials chemistry has been fundamental to the enormous field that encompasses the delivery of molecules both to desired sites and/or at desired rates and durations. The field encompasses the delivery of molecules including fertilizers, pesticides, herbicides, food ingredients, fragrances and biopharmaceuticals. A personal perspective is provided on our early work in this field that has enabled the controlled release of ionic substances and macromolecules. Also discussed are new paradigms in creating biomaterials for human use, the non-invasive delivery of molecules through the skin and lungs, the development of intelligent delivery systems and extensions to nanomedicine. With the advent of potentially newer biopharmaceutics such as siRNA, mRNA and gene editing approaches and their use being limited by delivery, future research in this field may be more critical than ever before.
材料化学对于一个庞大的领域至关重要，该领域涵盖了将分子递送至所需部位和/或以所需速率及持续时间进行递送。这个领域包括肥料、农药、除草剂、食品成分、香料和生物制药等分子的递送。文中提供了个人视角，讲述了我们在该领域的早期工作，这些工作实现了离子物质和大分子的控释。还讨论了用于人类的生物材料的新范例、分子通过皮肤和肺部的非侵入性递送、智能递送系统的开发以及向纳米医学的拓展。随着诸如siRNA、mRNA和基因编辑方法等潜在更新的生物制药的出现，且它们的应用受到递送的限制，该领域未来的研究可能比以往任何时候都更加关键。
