Li C X, Waters R S, Oladehin A, Johnson E F, McCandlish C A, Dykes R W
Department of Anatomy, University of Tennessee, College of Medicine, Memphis 38163.
Can J Neurol Sci. 1994 Aug;21(3):233-47. doi: 10.1017/s0317167100041214.
The organization of the primary somatosensory cortex innervated by the ulnar nerve was studied before and immediately after ulnar nerve transection in 11 cats electrophysiologically mapped under Nembutal or Ketamine anesthesia. The cortex was reexamined a second time beginning 42 hr after nerve transection in four cats anesthetized with Nembutal. One additional sham-operated control was also mapped. The region of cortex formerly served by the ulnar nerve remained largely unresponsive to somatic stimulation independent of the type of anesthetic used during recording. Nonetheless, animals anesthetized with Ketamine had more new responsive sites in deafferented cortex following nerve cut than cats anesthetized with Nembutal. New responses, when observed, were evoked by stimulation of a region of skin adjacent to the region served by the ulnar nerve. These findings suggest that the immediate response to deafferentation of somatosensory cortex is a limited acquisition of novel responses restricted to a region immediately adjacent to cortex containing normal afferent input.
在戊巴比妥或氯胺酮麻醉下，对11只猫进行电生理图谱绘制，研究尺神经切断术前及切断后即刻，由尺神经支配的初级体感皮层的组织情况。在4只接受戊巴比妥麻醉的猫中，于神经切断后42小时开始再次检查皮层。还对另外一只假手术对照猫进行了图谱绘制。无论记录过程中使用何种麻醉剂，以前由尺神经支配的皮层区域对躯体刺激基本无反应。然而，与戊巴比妥麻醉的猫相比，氯胺酮麻醉的动物在神经切断后去传入皮层中出现了更多新的反应位点。当观察到新反应时，是由刺激尺神经所支配区域相邻的皮肤区域诱发的。这些发现表明，体感皮层对去传入的即时反应是在紧邻含有正常传入输入的皮层区域有限地获得新反应。
