Klein G M, Rose M S, Seland T P
Department of Clinical Neurosciences, University of Calgary, Alberta, Canada.
Can J Neurol Sci. 1994 Aug;21(3):262-5. doi: 10.1017/s0317167100041251.
Reports of a high prevalence rate for multiple sclerosis in Southern Alberta led to an epidemiologic study of this disease in the Crowsnest Pass and Cardston regions. In Cardston, the prevalence rate for multiple sclerosis was 88 per 100,000. In the Crowsnest Pass, the prevalence rate was 217 per 100,000. Previous epidemiologic studies of the prevalence rate of multiple sclerosis in Western Canada have shown rates between 93 and 111 per 100,000. Two prevalence studies of multiple sclerosis in Barrhead County, Alberta and Westlock County, Alberta show prevalence rates of 196 and 201 per 100,000. The prevalence rate in the Crowsnest Pass is comparable to the prevalence in Barrhead County and Westlock County, Alberta. However, there is no statistically significant difference between prevalence rates in the Cardston and Crowsnest Pass regions and our overall feeling is that the results of studies of small populations should be interpreted with caution.
有报告称阿尔伯塔省南部多发性硬化症的患病率很高,这促使人们对克罗斯内斯特山口和卡德斯顿地区的这种疾病进行了一项流行病学研究。在卡德斯顿,多发性硬化症的患病率为每10万人88例。在克罗斯内斯特山口,患病率为每10万人217例。此前对加拿大西部多发性硬化症患病率的流行病学研究表明,患病率在每10万人93至111例之间。在阿尔伯塔省巴尔黑德县和韦斯特洛克县进行的两项多发性硬化症患病率研究显示,患病率分别为每10万人196例和201例。克罗斯内斯特山口的患病率与阿尔伯塔省巴尔黑德县和韦斯特洛克县的患病率相当。然而,卡德斯顿和克罗斯内斯特山口地区的患病率之间没有统计学上的显著差异,而且我们总体的感觉是,对小群体的研究结果应谨慎解读。