Metzger R, Bader M, Ludwig T, Berberich C, Bunnemann B, Ganten D
German Institute for High Blood Pressure Research, Heidelberg.
FEBS Lett. 1995 Jan 2;357(1):27-32. doi: 10.1016/0014-5793(94)01292-9.
We isolated the mas proto-oncogene from a mouse genomic library. Sequence analysis showed that it contains an open reading frame without intervening sequences. The amino acid sequence deduced confirms the seven-transmembrane-domain structure and exhibits 97% and 91% amino acid homology with the rat and the human Mas, respectively. In mice and rats, mas mRNA was detected in the testis, kidney, heart, and in the brain regions: hippocampus, forebrain, piriform cortex, and olfactory bulb. Testicular mas mRNA from rats increases markedly during development, while cerebellar mRNA is high postnatally but completely disappears at later stages. We conclude that the product of the mouse mas gene may be involved in the development of the brain and testis.
我们从小鼠基因组文库中分离出原癌基因mas。序列分析表明，它包含一个没有间隔序列的开放阅读框。推导的氨基酸序列证实了七跨膜结构域结构，并且分别与大鼠和人类的Mas具有97%和91%的氨基酸同源性。在小鼠和大鼠中，在睾丸、肾脏、心脏以及脑区：海马体、前脑、梨状皮质和嗅球中检测到mas mRNA。大鼠睾丸中的mas mRNA在发育过程中显著增加，而小脑mRNA在出生后较高，但在后期完全消失。我们得出结论，小鼠mas基因的产物可能参与大脑和睾丸的发育。
