Charbonnel B, Blanchard P
Clinique d'Endocrinologie, Maladies Métalobiques, Nutrition, Hôtel Dieu, Nantes, France.
Diabete Metab. 1994;20(2 Pt 2):194-205.
The replacement of some amino-acids in the insulin molecule results in analogues with improved therapeutic properties. Insulin analogues in a monomeric form are absorbed more quickly than hexameric insulin after subcutaneous administration. Bioactivity must be similar to that of insulin without any enhancement of mitogenic properties due to an increase of the affinity for IGF1 receptor. Lys B28-Pro B29 analogue is under clinical investigation to answer the following questions: does this analogue administered immediately before meal al decrease glycaemic excursions and the number of hypoglycemic episodes after meals compared to regular insulin administered 30 minutes before meal?
