Reviriego Fernández J
Departamento de Investigación Clínica, Lilly, S.A. Madrid.
An Med Interna. 1998 Jul;15(7):384-90.
Insulin lispro is an analog of human insulin created when the amino acids at positions 28 and 29 of the B-chain of insulin are reversed. The natural sequence in human insulin at these positions is proline at B28 and lysine at B29. At physiologic concentrations, insulin lispro exists in solution as a monomer. As such, it's rate of absorption from subcutaneous sites of injection is greater that of regular insulin. The pharmacokinetic and pharmacodynamic profiles of insulin lispro indicate that it is more rapid-acting, and therefore a more physiological mealtime insulin than regular insulin. In addition, it shows a shorter duration of activity, approximately up to 5 hours. Insulin lispro given 0 to 15 minutes before the meal translate into better glycemic control and less hypoglycemia risk in clinical studies either in type 1 or type 2 diabetes when compare with regular human insulin given 30-45 minutes before meals.
赖脯胰岛素是一种人胰岛素类似物，它是通过将胰岛素B链第28位和第29位的氨基酸顺序颠倒而产生的。人胰岛素在这些位置的天然序列是B28位为脯氨酸，B29位为赖氨酸。在生理浓度下，赖脯胰岛素在溶液中以单体形式存在。因此，它从皮下注射部位的吸收速度比常规胰岛素更快。赖脯胰岛素的药代动力学和药效学特征表明，它起效更快，因此与常规胰岛素相比，是一种更符合生理需求的餐时胰岛素。此外，它的作用持续时间较短，大约可达5小时。在1型或2型糖尿病的临床研究中，与在餐前30 - 45分钟注射常规人胰岛素相比，在餐前0至15分钟注射赖脯胰岛素可实现更好的血糖控制，且低血糖风险更低。
